Aspirin and Ibuprofen (and most other NSAIDs) cause gastrointestinal irritation and when mixed with alcohol can lead to bleeding in the GI tract. It's widely considered safer than alternatives like aspirin or ibuprofen. Advil is perfectly fine (occasionally) for a hangover. Conclusions: Ibuprofen is as or more efficacious than acetaminophen for the treatment of pain and fever in adult and pediatric populations and is equally safe. Jun 18, 2024 · See if it’s safe to take ibuprofen (Advil, Motrin) at the same time as acetaminophen (Tylenol). Alan Conway suggests considering alternative treatments instead of antibiotics for sinus infections, pointing out that many cases improve with home remedies. They are generally much more dangerous to mix with alcohol than tylenol because even mixing small amounts of alcohol and Aspirin just once carries considerate risk. Jan 1, 2026 · To do so may increase the chance of liver damage, especially if you drink large amounts of alcohol on a regular basis, if you take more acetaminophen than is recommended on the label, or if you take it regularly for a long time. May 22, 2024 · However, it doesn’t interact with naproxen (Aleve, Naprosyn), ibuprofen (Advil, Motrin), or acetaminophen (Tylenol). 4 days ago · When selecting an over-the-counter (OTC) pain reliever, consider acetaminophen for general pain and fever, and ibuprofen for conditions involving inflammation.

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